The TFPI Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to TFPI. This antibody recognizes Human, Mouse, and Rat antigen. The TFPI Antibody has been validated for the following applications: ELISA, Immunohistochemistry, and Western Blot.
Description
Description: This gene encodes a protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. The encoded protein is glycosylated and predominantly found in the vascular endothelium and plasma in both free forms and complexed with plasma lipoproteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been confirmed. [provided by RefSeq, Jul 2008]
Function: Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma.
Post-translational Modifications: O-glycosylated.
Similarity: This inhibitor contains three inhibitory domains. The first domain interacts with VIIa and TF, the second one with Xa